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Published byYulia Kurniawan Modified over 5 years ago
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Genomewide Significant Linkage to Migrainous Headache on Chromosome 5q21
Dale R. Nyholt, Katherine I. Morley, Manuel A.R. Ferreira, Sarah E. Medland, Dorret I. Boomsma, Andrew C. Heath, Kathleen R. Merikangas, Grant W. Montgomery, Nicholas G. Martin The American Journal of Human Genetics Volume 77, Issue 3, Pages (September 2005) DOI: /444510 Copyright © 2005 The American Society of Human Genetics Terms and Conditions
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Figure 1 Profile plot for the three symptomatic classes (CL1, CL2, and CL3) under the four-class model. Endorsement probabilities indicate the proportion of individuals in each class presenting with each symptom. All endorsement probabilities for CL0 were <0.005 (data not shown). Descriptions of symptom abbreviations are given in table 2. The American Journal of Human Genetics , DOI: ( /444510) Copyright © 2005 The American Society of Human Genetics Terms and Conditions
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Figure 2 Results of SOLAR genomewide multipoint linkage analysis for LCA migraine, showing thresholds for nominal P=.01 (dash-dot-dot line) and P=.05 (dotted line). The American Journal of Human Genetics , DOI: ( /444510) Copyright © 2005 The American Society of Human Genetics Terms and Conditions
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Figure 3 Results of MERLIN-regress genomewide multipoint linkage analysis for LCA migraine, showing thresholds obtained via simulation for significant linkage (dashed line) and suggestive linkage (dash-dot line). Thresholds estimated via linear regression for nominal P=.01 (dash-dot-dot line) and P=.05 (dotted line) are also displayed. The American Journal of Human Genetics , DOI: ( /444510) Copyright © 2005 The American Society of Human Genetics Terms and Conditions
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Figure 4 Results of MERLIN-regress chromosome-specific multipoint linkage analysis for LCA migraine and subphenotypes reaching nominal P≤.05. The American Journal of Human Genetics , DOI: ( /444510) Copyright © 2005 The American Society of Human Genetics Terms and Conditions
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