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Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma 

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Presentation on theme: "Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma "— Presentation transcript:

1 Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma  Christian Hahn, a, Martin Teufel, a, Udo Herz, PhDb, Harald Renz, MDb, Klaus J. Erb, PhDc, Gisela Wohlleben, PhDc, Eva B. Bröcker, MDa, Albert Duschl, PhDd, Walter Sebald, PhDe, Susanne M. Grunewald, MD, PhDa  Journal of Allergy and Clinical Immunology  Volume 111, Issue 6, Pages (June 2003) DOI: /mai Copyright © 2003 Mosby, Inc. Terms and Conditions

2 Fig. 1 Serum IgE titers. IgE titers were determined by ELISA 6 weeks after completion of the sensitization and therapy courses or 9 weeks with an allergen-free interval (Table I). Data are given as means of 2-4 animal experiments (n = 5-30) ± SD. *P < .001, Mann-Whitney rank sum test. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

3 Fig. 2 IL-5 levels in the BALs. IL-5 levels are measured by ELISA 6 weeks after completion of the sensitization and therapy courses (Table I). Data are given as means (n = 5-8) ± SD. *P < 05, unpaired t test. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

4 Fig. 3 Allergic airway pathologic condition. Lung sections were stained with H&E (A and B ) or PAS (C) to detect inflammatory infiltrates and goblet cell metaplasia 6 weeks after completion of the sensitization and therapy courses (Table I). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

5 Fig. 4 Airway eosinophilia. BAL was performed and the amount of eosinophils was determined 6 weeks (A) after completion of the sensitization and therapy courses (Table I) or 9 weeks with an allergen-free interval (B) . Data are means (n = 5-19) ± SD from 2-4 animal experiments. *P < .001, unpaired t test. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions


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