1. Association Between Nonalcoholic Hepatic Steatosis and Hepatic Cytochrome P-450 3A Activity 
Dhanashri Kolwankar, Raj Vuppalanchi, Brian Ethell, David R. Jones, Steven A. Wrighton, Stephen D. Hall, Naga Chalasani 
Clinical Gastroenterology and Hepatology 
Volume 5, Issue 3, Pages (March 2007)
DOI: /j.cgh
Copyright © 2007 AGA Institute Terms and Conditions

2. Figure 1
(A) Relationship between CYP3A5 genotype and expression of wt and SV1 mRNA in subjects who express at least one CYP3A5*1 allele (n = 12; one subject with genotype CYP3A5*1/*1, *1/*6, *1/*7 was not included because of inability to precisely characterize the genotype) and CYPA5*3/*3 (n = 34; no RNA could be isolated from 2 samples). Relative mRNA values are in attograms/attograms after normalization to 18S RNA used as a housekeeping gene. (B) Relationship between CYP3A5 genotype in subjects who express at least one CYP3A5*1 allele (n = 12; one subject with genotype CYP3A5*1/*1, *1/*6, *1/*7 was excluded from analysis because of inability to precisely characterize the genotype) and CYPA5*3/ *3 (n= 34; no RNA could be isolated from 2 samples) with their CYP3A4 mRNA expression and CYP3A activity. Data are shown as mean ± standard error.
Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh )
Copyright © 2007 AGA Institute Terms and Conditions

3. Figure 2
Relationship between hepatic CYP3A activity and severity of steatosis. Steatosis was categorized into none (n = 25), mild (≥5%–33% steatosis) (n = 20) or moderate steatosis (>33%) (n = 4). Data are shown as mean ± standard error.
Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh )
Copyright © 2007 AGA Institute Terms and Conditions