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Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure Milos Brankovic, K. Martijn Akkerhuis, Henk Mouthaan, Alina Constantinescu, Kadir Caliskan, Jan van Ramshorst, Tjeerd Germans, Victor Umans, Isabella Kardys International Journal of Cardiology Volume 276, Pages (February 2019) DOI: /j.ijcard Copyright © 2018 The Authors Terms and Conditions
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Fig. 1 Average temporal evolution of candidate biomarkers during follow-up. Legend: Average evolution in patients who reached the composite endpoint (solid red line), and in endpoint-free patients (solid blue line). Dashed lines represent the 95% confidence interval. X-axis depicts the time from baseline (left part of the x-axis), and time remaining to the event (patients who experienced incident events) or last sample moment (patients who remained event-free) (right part of the x-axis). Biomarker levels are presented on the y-axis. a. Osteopontin (OPN), b. Osteoprotegerin (OPG), c. Epidermal growth factor receptor (EGFR), d. Heparin-binding protein (HBP), e. Trefoil factor-3 (TFF-3), f. Kallikrein-6 (KLK-6) g. Matrix extracellular phosphoglycoprotein (MEPE). h. Pulmonary surfactant-associated protein-D (PSP-D) i. Secretoglobulin family 3A-member-2 (SCGB3A2). International Journal of Cardiology , DOI: ( /j.ijcard ) Copyright © 2018 The Authors Terms and Conditions
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