Presentation is loading. Please wait.

Presentation is loading. Please wait.

Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults  Christian Lupinek, MD,

Published byBeverly Shepherd Modified over 6 years ago

Similar presentations

Presentation on theme: "Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults  Christian Lupinek, MD,"— Presentation transcript:

1 Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults  Christian Lupinek, MD, Katharina Marth, MD, Verena Niederberger, MD, Rudolf Valenta, MD  Journal of Allergy and Clinical Immunology  Volume 130, Issue 6, Pages e4 (December 2012) DOI: /j.jaci Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 IgE reactivity profiles in 1997 and 2007 assessed by means of microarray for a representative patient. Scans of the microarrays incubated with serum samples collected in 1997 (left) and 2007 (right) are shown, Allergens are spotted in triplicates. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Changes in IgE reactivities to families of cross-reactive allergens between 1997 and Displayed are new (red bar) and lost (blue bars) reactivities to families of cross-reactive allergens (y-axis) for patients A1 to A12 (x-axis) adjusted by CAP results. Numbers of positive allergen families in 1997 are shown in brackets for each patient (x-axis). Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Families of tested allergens and summary of reactivities. Allergens belonging to the same cross-reactive allergen family (left column) were grouped in individual boxes (route of exposure: green, Airborne allergens; orange, food allergens; and yellow, venom allergens). The right column displays the numbers of positive sera in 1997 and Total numbers of allergen families and allergens recognized in 1997, 2007, or both are shown (bottom line, purple boxes). nsLTP, Nonspecific lipid transfer protein; PR-10, pathogenesis-related protein family 10. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Demographic and clinical characterization of allergic patients (A1-12) and nonallergic subjects (N1-N10). f, Female; m, male. Allergies: a, animals; f, food; g, grass pollen; mi, mites; t, tree pollen; w, weed pollen. Symptoms: as, asthma; c, conjunctivitis; d, dermatitis; oas, oral allergy syndrome; r, rhinitis. Symptomatic therapy: ah, antihistamine; nc, nasal corticosteroid; tc, topical (dermal) corticosteroid. Dashes indicate lack of allergy, symptoms, or therapy. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E3 Detailed analysis of IgE reactivities and their changes for each subject. Numbers of recognized allergen molecules and allergen families in 1997 and 2007, as well as changes in 2007 versus 1997, are shown. Allergens that were negative by means of chip but positive by means of CAP in 1997 are printed in red. PR10, Pathogenesis-related protein family 10. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E4 Results of CAP measurements for sera that were negative to certain allergens in ISAC in 1997 but positive in kUA/l, Kilounits of antigen-specific IgE per liter. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults  Christian Lupinek, MD,"

Similar presentations

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,
Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy  Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy  Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.
Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies  Marija Geroldinger-Simic, MD, Thomas Zelniker,

Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies  Marija Geroldinger-Simic, MD, Thomas Zelniker,
Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.

Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.
Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R

Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Eosinophilic gastrointestinal disease suggestive of pathogenesis-related class 10 (PR- 10) protein allergy resolved after immunotherapy  Liliane De Swert,

Eosinophilic gastrointestinal disease suggestive of pathogenesis-related class 10 (PR- 10) protein allergy resolved after immunotherapy  Liliane De Swert,
Margaretha A. Faber, MD, PhD, Athina L. Van Gasse, MD, Ine I

Margaretha A. Faber, MD, PhD, Athina L. Van Gasse, MD, Ine I
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Prediction of IgE-binding epitopes by means of allergen surface comparison and correlation to cross-reactivity  Fabio Dall'Antonia, PhD, Anna Gieras,

Prediction of IgE-binding epitopes by means of allergen surface comparison and correlation to cross-reactivity  Fabio Dall'Antonia, PhD, Anna Gieras,
Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.

Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.
Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy  Margarete Focke-Tejkl, PhD, Milena.

Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy  Margarete Focke-Tejkl, PhD, Milena.
Skin test diagnosis of grass pollen allergy with a recombinant hybrid molecule  Carine Metz-Favre, MD, Birgit Linhart, PhD, Margarete Focke-Tejkl, PhD,

Skin test diagnosis of grass pollen allergy with a recombinant hybrid molecule  Carine Metz-Favre, MD, Birgit Linhart, PhD, Margarete Focke-Tejkl, PhD,
Act d 12 and Act d 13: Two novel, masked, relevant allergens in kiwifruit seeds  Sofía Sirvent, PhD, Belén Cantó, BSc, Javier Cuesta-Herranz, MD, PhD,

Act d 12 and Act d 13: Two novel, masked, relevant allergens in kiwifruit seeds  Sofía Sirvent, PhD, Belén Cantó, BSc, Javier Cuesta-Herranz, MD, PhD,
Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 
Persistence of the IgE repertoire in birch pollen allergy

Persistence of the IgE repertoire in birch pollen allergy
Primary respiratory and food allergy to mealworm

Primary respiratory and food allergy to mealworm
Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.
Bruce M. Prenner, MD, Bobby Q. Lanier, MD, David I

Bruce M. Prenner, MD, Bobby Q. Lanier, MD, David I

Similar presentations

Ads by Google