1. Challenges in Severe Asthma

2. Severe Asthma Has a Huge Burden

3. Asthma Is a Heterogeneous Disease

4. Defining Severe and Uncontrolled Asthma

5. Case Leon

6. History and Work-Up

7. Comorbidities

8. History and Work-Up (cont)

9. Asthma Phenotypes and Endotypes

10. Pathophysiology T2 Asthma and Eosinophils

11. Pathophysiology T2 Asthma and ILC2 Cells

12. Pathophysiology Non-T2 Asthma

13. Leon Treatment Options

14. Biomarkers

15. Biomarkers Results

16. IL-5 Targeted Agents for Eosinophilic Asthma

17. Other Targeted Agents

18. Options for Non-T2 Asthma

19. Concluding Remarks

20. Abbreviations

21. Abbreviations (cont)