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Volume 44, Issue 1, Pages (January 2006)

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Presentation on theme: "Volume 44, Issue 1, Pages (January 2006)"— Presentation transcript:

1 Volume 44, Issue 1, Pages 134-141 (January 2006)
Characterization of acute liver failure and development of a continuous risk of death staging system in children  Edwin Liu, Todd MacKenzie, Emily L. Dobyns, Chirag R. Parikh, Frederick M. Karrer, Michael R. Narkewicz, Ronald J. Sokol  Journal of Hepatology  Volume 44, Issue 1, Pages (January 2006) DOI: /j.jhep Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

2 Fig. 1 (A) Survival without liver transplant was stratified by four levels (quartiles) of risk of death staging based on the final model to derive a liver injury units (LIU) score using peak PT: LIU=3.584×peak total bilirubin (mg/dl)+1.809×peak PT (seconds)+0.307×NH3 (μmol/l). The risk of death staging uses the first two quartiles to represent low risk of death (≤84). Moderate (85–138) and high (≥139) risk of death or need for liver transplantation is shown in the upper two quartiles of the score. (B) Survival without liver transplant by quartiles of risk of death stage based on the final model using peak INR: LIU=3.507×peak total bilirubin+54.51×peak INR+0.254×peak NH3. The risk of death staging uses the first two quartiles to represent low risk of death (≤295). Moderate (296–367) and high (≥368) risks of death or need for liver transplantation is shown in the upper two quartiles of the score. [This figure appears in colour on the web.] Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

3 Fig. 2 ROC curves for predicting death or transplant using LIU score as calculated with INR (panel A) or with PT (panel B). Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions


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