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Volume 15, Issue 11, Pages (November 2008)

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1 Volume 15, Issue 11, Pages 1198-1206 (November 2008)
Improved Antifungal Polyene Macrolides via Engineering of the Nystatin Biosynthetic Genes in Streptomyces noursei  Trygve Brautaset, Håvard Sletta, Aina Nedal, Sven Even F. Borgos, Kristin F. Degnes, Ingrid Bakke, Olga Volokhan, Olga N. Sekurova, Ivan D. Treshalin, Elena P. Mirchink, Alexander Dikiy, Trond E. Ellingsen, Sergey B. Zotchev  Chemistry & Biology  Volume 15, Issue 11, Pages (November 2008) DOI: /j.chembiol Copyright © 2008 Elsevier Ltd Terms and Conditions

2 Figure 1 Proposed Nystatin Biosynthesis in Streptomyces noursei
Only reductive domains in the nystatin PKS modules are shown. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2008 Elsevier Ltd Terms and Conditions

3 Figure 2 Genetically Engineered Polyene Macrolides
(A) Molecular structures of nystatin and its analogs generated by biosynthetic engineering. (B) Molecular structures of amphotericin B analogs produced via manipulation of biosynthetic genes (Carmody et al., 2005; Power et al., 2008). Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2008 Elsevier Ltd Terms and Conditions

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