1. Rationale for the use of structure-modifying drugs and agents in the treatment of osteoarthritis 
Jean-Pierre Pelletier, MD 
Osteoarthritis and Cartilage 
Volume 12, Pages (January 2004)
DOI: /j.joca

2. Fig. 1
Global interaction of catabolic pathways in osteoarthritic tissues, which are responsible for the structural changes of the disease. (Reproduced with permission. Henrotin Y, Reginster J-Y. Le cartilage articulaire peut-il se régénérer? Le généraliste 1988;415:11.)
Osteoarthritis and Cartilage  , 63-68DOI: ( /j.joca )

3. Fig. 2
Schematic representation of the role of the inducible form of nitric oxide synthase (iNOS) and nitric oxide (NO) in the pathophysiology of osteoarthritis. (Reproduced from Arthritis and Allied Conditions. A Textbook of Rheumatology, 14th edition, Baltimore, MD: Lippincott, Williams & Wilkins, 2000; pp.2195–2215, Figure 110.3, with permission from Lippincott, Williams & Wilkins.)
Osteoarthritis and Cartilage  , 63-68DOI: ( /j.joca )

4. Fig. 3
Schematic representation of the mechanisms involved in the remodeling of osteoarthritic subchondral bone and possible interaction with cartilage. (Reproduced from JY Reginster, JP Pelletier, J Martel-Pelletier, Y Henrotin, Eds. Osteoarthritis: Clinical and Experimental Aspects, Heidelberg, Germany: Springer-Verlag, 1999, pp. 156–187, Fig. 2, with permission from Springer-Verlag GmbH & Co. KG.)
Osteoarthritis and Cartilage  , 63-68DOI: ( /j.joca )