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Targeting the Undruggable Proteome: The Small Molecules of My Dreams
Craig M. Crews Chemistry & Biology Volume 17, Issue 6, Pages (June 2010) DOI: /j.chembiol Copyright © 2010 Elsevier Ltd Terms and Conditions
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Figure 1 Strategies for Using Cellular Protein Degradation Machinery to Control Intracellular Protein Levels (A) Schematic of inducing protein degradation via recruitment to the proteasome or lysosome. (B) Design of a PROTAC-based library targeting protein function independently of protein class. Chemistry & Biology , DOI: ( /j.chembiol ) Copyright © 2010 Elsevier Ltd Terms and Conditions
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