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Volume 24, Issue 2, Pages (August 2016)

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1 Volume 24, Issue 2, Pages 283-294 (August 2016)
Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier  Hong Ma, Nuria Marti Gutierrez, Robert Morey, Crystal Van Dyken, Eunju Kang, Tomonari Hayama, Yeonmi Lee, Ying Li, Rebecca Tippner-Hedges, Don P. Wolf, Louise C. Laurent, Shoukhrat Mitalipov  Cell Metabolism  Volume 24, Issue 2, Pages (August 2016) DOI: /j.cmet Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Cell Metabolism 2016 24, 283-294DOI: (10.1016/j.cmet.2016.06.012)
Copyright © 2016 Elsevier Inc. Terms and Conditions

3 Figure 1 mtDNA Heteroplasmy Segregation in Individual Pups of MR1 and MR2 (A) Percentages of donor PWD mtDNA allele in individual stillborn and live MR1 pups with B6 nuclear genome. (B) Percentages of donor B6 mtDNA allele in individual stillborn and live MR2 pups with PWD nuclear genome. (C) Heteroplasmy percentages of host PWD mtDNA (pink) and donor B6 mtDNA allele (green) in various tissues collected from one live and one stillborn pup (3 in B) in MR2. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2016 Elsevier Inc. Terms and Conditions

4 Figure 2 Diagrammatic Representation of Reciprocal Intersubspecies MR between B6, PWD, B6-DBA, and PWD-DBA Zygotes Reconstructed embryos were tested for their post-implantation developmental potential after transfer to recipients. MR1 embryos supported normal development of F1 offspring with reduced male fertility but unaffected reproductive fitness in females. Embryos in MR2 mostly resulted in stillborns, reflecting incompatibility of the PWD nDNA and B6 mtDNA genome. The only surviving F1 female was infertile. Development of cybrid MR3 embryos with heterozygous B6-DBA nDNA and PWD mtDNA was similar to controls. Inclusion of DBA chromosomes along with PWD nDNA rescued development of hybrid embryos in MR4. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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