1. HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL 
Christopher J. Ott, Catherine J. Wu 
Cancer Cell 
Volume 32, Issue 1, Pages 1-3 (July 2017)
DOI: /j.ccell
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Use of ATAC-seq to Reveal Chromatin Accessibility Profiles of CTCL
(A) Flow-sorted populations of CD4+ T cells from healthy donors and CTCL patients used for ATAC-seq profiling. Leukemic cell populations were purified from host T cells via the unique Vβ receptor.
(B) ATAC-seq on each population revealed profiles of active cis-regulatory elements, with evidence of population-distinct gene signatures, unique transcription factor circuits associated with response or resistance to HDACi, and correlations with subsets of memory T cells.
(C) Chromatin states during HDACi therapy were assessed, revealing that response is associated with pharmacodynamic increase in baseline regulatory element accessibility and apparent normalization of host T cell chromatin signatures.
Cancer Cell  , 1-3DOI: ( /j.ccell )
Copyright © 2017 Elsevier Inc. Terms and Conditions