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Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects

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1 Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects
Eun Hee Koh, MD, Woo Je Lee, MD, Sang Ah Lee, MD, Eun Hee Kim, MD, Eun Hee Cho, MD, Eunheui Jeong, MD, Dong Woo Kim, MD, Min-Seon Kim, MD, Joong-Yeol Park, MD, Keun-Gyu Park, MD, Hyo-Jung Lee, PhD, In-Kyu Lee, MD, Soo Lim, MD, Hak Chul Jang, MD, Ki Hoon Lee, PhD, Ki-Up Lee, MD  The American Journal of Medicine  Volume 124, Issue 1, Pages 85.e1-85.e8 (January 2011) DOI: /j.amjmed Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Disposition of subjects enrolled in the study. LA=alpha-lipoic acid. The American Journal of Medicine  , 85.e1-85.e8DOI: ( /j.amjmed ) Copyright © 2011 Elsevier Inc. Terms and Conditions

3 Figure 2 Mean change in body weight from baseline during 20 weeks of treatment with placebo or 1200 or 1800 mg/d alpha-lipoic acid (intent-to-treat subjects). Data are reported as mean±standard error of the mean. *P<.05 vs baseline for that group; **P<.05 vs placebo. LA=alpha-lipoic acid. The American Journal of Medicine  , 85.e1-85.e8DOI: ( /j.amjmed ) Copyright © 2011 Elsevier Inc. Terms and Conditions

4 Figure 3 Mean weight loss at 20 weeks in intent-to-treat subjects (A) and per-protocol completers (B). Data are reported as mean±standard error of the mean. *P<.05 vs placebo. LA=alpha-lipoic acid; ITT=intent-to-treat; PPC=per-protocol completers. The American Journal of Medicine  , 85.e1-85.e8DOI: ( /j.amjmed ) Copyright © 2011 Elsevier Inc. Terms and Conditions

5 Figure 4 Percentage of subjects in each group who lost≥5% of initial body weight (intent-to-treat subjects). *P<.01 vs placebo. LA=alpha-lipoic acid. The American Journal of Medicine  , 85.e1-85.e8DOI: ( /j.amjmed ) Copyright © 2011 Elsevier Inc. Terms and Conditions


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