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Aspirin resistance among long-term aspirin users after carotid endarterectomy and controls: Flow cytometric measurement of aspirin-induced platelet inhibition 

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Presentation on theme: "Aspirin resistance among long-term aspirin users after carotid endarterectomy and controls: Flow cytometric measurement of aspirin-induced platelet inhibition "— Presentation transcript:

1 Aspirin resistance among long-term aspirin users after carotid endarterectomy and controls: Flow cytometric measurement of aspirin-induced platelet inhibition  Afshin Assadian, MD, Jaqueline Lax, MS, Ursula Meixner-Loicht, MD, Georg W. Hagmüller, MD, Peter Michael Bayer, MD, Wolfgang Hübl, MD  Journal of Vascular Surgery  Volume 45, Issue 6, Pages (June 2007) DOI: /j.jvs Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Activation of platelets by arachidonic acid (ARA): all 86 patients receiving long-term low-dose aspirin medication (ASP) showed inhibition of ARA-induced platelet activation (ie, <15% CD62p-positive platelets), whereas two of 29 patient controls without reported history of aspirin intake (PCON) demonstrated cyclooxygenase inhibition. The threshold of 15% is marked by the dashed line. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 PFA-100 collagen-epinephrine closure time (CEPI-CT): 14 of 86 patients showed a normal CEPI-CT despite long-term low-dose aspirin medication (ASP). Four of 29 patient controls without an apparent history of aspirin intake (PCON) had an elevated CEPI-CT. The upper reference limit (165 seconds) is marked by the dashed line. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions


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