1. Lipids and lipoproteins as coronary risk factors in non-insulin-dependent diabetes mellitus 
Mikko Syvänne, MD, Marja-Riitta Taskinen, MD 
The Lancet 
Volume 350, Pages S20-S23 (July 1997)
DOI: /S (97)
Copyright © 1997 Elsevier Ltd Terms and Conditions

2. Figure Dyslipidaemia of NIDDM
Increased production of VLDL by the liver, high triglyceride (TG) concentrations after a fatty meal, and low lipoprotein lipase activity lead to raised concentrations of TG-rich lipoproteins (TG-rL) in plasma. High TG-rL concentrations increase the transfer of TG to LDL and HDL and a concomitant transfer of cholesteryl esters (CE) from LDL and HDL to TG-rL—all these reactions are mediated by cholesteryl-ester transfer protein (CETP). Hydrolysis of core TG by hepatic lipase produces small and dense HDL particles that have high fractional catabolic rates (0·63 [0·07] 1/day in NIDDM patients vs 0·39 [0·021] 1/day in non-diabetic individuals). Similarly, small and dense LDL particles predominate, and are also seen on gradient gel electrophoresis as pattern B. Modified and reproduced with permission of the Endocrine Society from Golay A et al, J Clin Endocrinol Metab 1987; 65: 512–18.
The Lancet  , S20-S23DOI: ( /S (97) )
Copyright © 1997 Elsevier Ltd Terms and Conditions