1. MicroRNAs and Parallel Stem Cell Lives
Peter B. Dirks 
Cell 
Volume 138, Issue 3, Pages (August 2009)
DOI: /j.cell
Copyright © 2009 Elsevier Inc. Terms and Conditions

2. Figure 1 MicroRNAs Target BMI1 to Block Self-Renewal
MicroRNA-200c (miR-200c) shows decreased expression in breast cancer stem cells compared to cancer cells in the bulk tumor. Normal mammary epithelial stem cells show lower expression of miR-200c than differentiated cells. It is possible that miR-200c blocks stem cell self-renewal by targeting the 3′UTR of the self-renewal gene BMI1, resulting in loss of BMI1 protein,and attenuation of the ability of cancer stem cells to self-renew and form tumors.
Cell  , DOI: ( /j.cell )
Copyright © 2009 Elsevier Inc. Terms and Conditions