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Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis  Jeremy.

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Presentation on theme: "Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis  Jeremy."— Presentation transcript:

1 Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis  Jeremy Puthumana, Xavier Ariza, Justin M. Belcher, Isabel Graupera, Pere Ginès, Chirag R. Parikh  Clinical Gastroenterology and Hepatology  Volume 15, Issue 7, Pages e3 (July 2017) DOI: /j.cgh Copyright © 2017 AGA Institute Terms and Conditions

2 Figure 1 Flow diagram of study selection.
Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions

3 Figure 2 Sensitivity and specificity of (A) urine IL18 and (B) urine NGAL for the diagnosis of ATN. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions

4 Figure 3 AUC of (A) urine IL18 and (B) urine NGAL for the diagnosis of ATN. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions

5 Figure 4 Sensitivity and specificity of (A) urine IL18 and (B) urine NGAL for predicting all-cause mortality. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions

6 Figure 5 AUC of (A) urine IL18 and (B) urine NGAL for predicting all-cause mortality. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions

7 Supplementary Figure 1 Funnel plots for the assessment of potential publication bias. (A) Urine IL18 for the diagnosis of ATN. (B) Urine NGAL for the diagnosis of ATN. (C) Urine IL18 for predicting all-cause mortality. (D) Urine NGAL for predicting all-cause mortality. dOR, diagnostic odds ratio. Clinical Gastroenterology and Hepatology  , e3DOI: ( /j.cgh ) Copyright © 2017 AGA Institute Terms and Conditions


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