1. Volume 146, Issue 4, Pages 970-979.e6 (April 2014)
Baseline Values and Changes in Liver Stiffness Measured by Transient Elastography Are Associated With Severity of Fibrosis and Outcomes of Patients With Primary Sclerosing Cholangitis 
Christophe Corpechot, Farid Gaouar, Ahmed El Naggar, Astrid Kemgang, Dominique Wendum, Raoul Poupon, Fabrice Carrat, Olivier Chazouillères 
Gastroenterology 
Volume 146, Issue 4, Pages e6 (April 2014)
DOI: /j.gastro
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2. Figure 1
Box plot of LSM depending on histological fibrosis stage. The bottom and top of the boxes are the first and third quartiles (interquartiles), and the band inside the boxes is the median. The ends of the whiskers are the minimum and maximum of the data, and the horizontal stroke is the mean.
Gastroenterology  , e6DOI: ( /j.gastro )
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3. Figure 2
Scatter plots showing the correlations between the VCTE ratings (A) of 2 operators at the same measurement site and (B) those obtained by a single operator at 2 adjacent sites (seventh and eighth intercostal spaces). The ratings are presented on a logarithmic scale.
Gastroenterology  , e6DOI: ( /j.gastro )
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4. Figure 3
Changes in LSM as estimated by the linear mixed model (A) as a function of time and initial stage of fibrosis or (B) as a single continuous process extrapolated from the means of progression rates.
Gastroenterology  , e6DOI: ( /j.gastro )
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5. Figure 4
Survival rates without adverse outcomes according to different cutoff values of LSM (A–C) at baseline and (D–F) of LSM progression rate ΔLSM/∂t. LSM was strongly linked to risk of death, liver transplantation, or hepatic complications.
Gastroenterology  , e6DOI: ( /j.gastro )
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6. Supplementary Figure 1
Box plot of LSM in the subgroup of patients with elevated bilirubin levels.
Gastroenterology  , e6DOI: ( /j.gastro )
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7. Supplementary Figure 2
Receiver-operating characteristic curves of LSM, hyaluronic acid concentration, APRI score, FIB-4 score, and Mayo risk score for the diagnosis of (A) significant fibrosis (F2, F3, F4), (B) severe fibrosis (F3, F4), or (C) cirrhosis (F4).
Gastroenterology  , e6DOI: ( /j.gastro )
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8. Supplementary Figure 3
Difference plot showing the difference between the ratings of 2 operators and the average of both ratings. The average (x-axis) is shown on a logarithmic scale. Thick dotted lines represent the 95% CI of the differences, and thin dotted lines represent the average and 95% CI of bias.
Gastroenterology  , e6DOI: ( /j.gastro )
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9. Supplementary Figure 4
Spaghetti plot showing the individual changes in LSM observed in 146 patients with PSC. Each colored line corresponds to the course of LSM for a given subject.
Gastroenterology  , e6DOI: ( /j.gastro )
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10. Supplementary Figure 5
Receiver-operating characteristic curves of changes in LSM (ΔLSM/∂t) and Mayo risk score (ΔMayo score/∂t) for the prediction of adverse outcomes (AUROC, 0.84 ± 0.06 and 0.83 ± 0.06, respectively; P = NS).
Gastroenterology  , e6DOI: ( /j.gastro )
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11. Supplementary Figure 6
Box plots of (A) LSM and (B) ΔLSM/∂t in patients with or without an ALP level <1.5 times the upper limit of normal after at least 1 year of follow-up from diagnosis.
Gastroenterology  , e6DOI: ( /j.gastro )
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