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Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis  Juan Wen, B.S., Jie Jiang, B.S.,

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Presentation on theme: "Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis  Juan Wen, B.S., Jie Jiang, B.S.,"— Presentation transcript:

1 Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis  Juan Wen, B.S., Jie Jiang, B.S., Chenyue Ding, B.S., Juncheng Dai, M.D., Yao Liu, B.S., Yankai Xia, M.D., Ph.D., Jiayin Liu, M.D., Ph.D., Zhibin Hu, M.D., Ph.D.  Fertility and Sterility  Volume 97, Issue 6, Pages e4 (June 2012) DOI: /j.fertnstert Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Flow chart of study selection in review of the effect of IVF and ICSI on birth defects. ART = assisted reproductive technologies; IVF = in vitro fertilization; ICSI = intracytoplasmic sperm injection; SC = spontaneously conceived children. *Including articles not published in English or Chinese. Fertility and Sterility  , e4DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Individual risk ratio estimates and pooled ratio estimates from the studies relating IVF and ICSI children compared with spontaneously conceived children. Abbreviations as in Fig. 1. *Weight from random effects analysis. Fertility and Sterility  , e4DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Individual risk ratio estimates and pooled risk ratio estimates from studies relating birth defects in children conceived by IVF compared with ICSI. Abbreviations as in Fig. 1. *Weight form random effects analysis. Fertility and Sterility  , e4DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

5 Supplemental Figure 1 Funnel plot of log (RR) against SE of log (RR) for studies relating birth defects in IVF and/or ICSI children compared with spontaneously conceived children. Fertility and Sterility  , e4DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

6 Supplemental Figure 2 Funnel plot of log (RR) against SE of log (RR) for studies relating birth defects in children conceived by IVF compared with by ICSI. Fertility and Sterility  , e4DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions


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