1. Arginine Arms T Cells to Thrive and Survive
Rigel J. Kishton, Madhusudhanan Sukumar, Nicholas P. Restifo 
Cell Metabolism 
Volume 24, Issue 5, Pages (November 2016)
DOI: /j.cmet
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2. Figure 1 Arginine Promotes T Cell Memory Phenotype Acquisition
Increased levels of arginine in T cells result in the inhibition of glucose uptake and the promotion of mitochondrial oxidative metabolism. Concurrently, arginine modulates the conformation of several proteins involved in chromatin regulation. Together, these alterations in cell metabolism and perhaps gene expression driven by arginine promote the acquisition of a memory phenotype in T cells. This phenotype results in increased T cell survival, persistence, and an improved antitumor response.
Cell Metabolism  , DOI: ( /j.cmet )
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