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Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression
Yu Shi, Yi-fang Ping, Xia Zhang, Xiu-wu Bian Cell Stem Cell Volume 16, Issue 3, Pages (March 2015) DOI: /j.stem Copyright © 2015 Elsevier Inc. Terms and Conditions
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Figure 1 Glioma Stem Cells Recruit Monocyte-Derived Tumor-Associated Macrophages to Promote Glioblastoma Tumor Growth (A) Glioma stem cells (GSCs) in perivascular niches secrete Periostin (POSTN) to attract circulating monocytes. (B) The emigration and differentiation of recruited monocytes in GSC niches. (C) POSTN maintains M2 tumor-associated macrophages (TAMs) that promote tumor growth. (D) Targeting POSTN or GSCs attenuates the recruitment of M2 TAMs and halts glioblastoma (GBM) tumor progression. Cell Stem Cell , DOI: ( /j.stem ) Copyright © 2015 Elsevier Inc. Terms and Conditions
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