1. Treating Leukemia in Youths
Zachary Smith and Theren Williams
University of Michigan – Dearborn
BACKGROUND
METHODS
RESULTS
CONCLUSIONS
National Cancer Institute SEER ( )
Leukemia: cancer of the blood cell
3.5% of new cancer diagnoses
29% of new childhood cancer diagnoses
18,059 patients diagnosed between years 1973 and 2014 and from areas within the United States
Contains primary sites in Leukemia and Hodgkin Lymphoma primarily
Youth: ages 0 to 19 years old at diagnosis
First 5 Years’ Survival Probability Analysis
Probability of surviving 5 years after diagnosis (given treatment, age, etc.)
Unreplicated Factorial Design with Type III ANOVA
Survival Analysis
Kaplan-Meier Survival Model
Cox Proportional Hazard Model
Chemotherapy significantly increases survival probability.
Not all treatments were significant.
Radiation alone was not significant.
Chemotherapy alone had higher survival than radiation alone.
Both treatments were not significantly higher in survival than either treatment alone.
Age Group is significant.
Ages 0-4 and 5-9 had higher survival probability (Leukemia Only).
Patients of 10 years or older showed higher survival probability when treated by radiation (All Patients).
Time period diagnosed is significant.
Recent years have better survival.
CoxPH with All (Base: Neither Treatment)
Chemotherapy and Radiation significantly increase probability of surviving when given separately. Whereas, when given together it showed significantly lower survival.
CoxPH with Leukemia Patients Only
Chemotherapy showed significantly higher survival probability compared to Radiation and Both treatments.
ACKNOWLEDGMENT
UM-Dearborn scholar grant
Advisors: Keshav Pokhrel and Taysseer Sharaf
REFERENCES
NCI. "SEER Data & Software." National Cancer Institute, Nov. 2016,
Accessed 3 Jan
CTCA. "Leukemia." Cancer Treatment Centers of America, 22 Feb. 2017,
Accessed 2 Feb
American Cancer Society, . "Cancer Facts & Figures 2018." American Cancer
Society, Accessed 30 Apr. 2018