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Volume 147, Issue 1, Pages (January 2015)

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1 Volume 147, Issue 1, Pages 46-55 (January 2015)
Association Between Pathogens Detected Using Quantitative Polymerase Chain Reaction With Airway Inflammation in COPD at Stable State and Exacerbations  Bethan L. Barker, BMBS, Koirobi Haldar, MSc, Hemu Patel, BSc, Ian D. Pavord, MD, Michael R. Barer, PhD, Christopher E. Brightling, PhD, FCCP, Mona Bafadhel, PhD  CHEST  Volume 147, Issue 1, Pages (January 2015) DOI: /chest Copyright © 2015 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Proportional Venn diagram depicting the distribution of qPCR codetection at baseline for all subjects. H. influenzae = Haemophilus influenzae; HI = Haemophilus influenzae; M. catarrhalis = Moraxella catarrhalis; MC = Moraxella catarrhalis; qPCR = quantitative polymerase chain reaction; S. pneumoniae = Streptococcus pneumoniae;SP = Streptococcus pneumoniae. CHEST  , 46-55DOI: ( /chest ) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

3 Figure 2 A-F, Correlations between the sputum mediator concentrations (A) TNFα, (B) IL1β, (C) IL8, (D) IL6, (E) IL10, and (F) CXCL10 and sputum bacterial load of HI, MC, and SP. TNF = tumor necrosis factor. See Figure 1 legend for expansion of other abbreviations. CHEST  , 46-55DOI: ( /chest ) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

4 Figure 3 A-F, Correlations between the sputum mediator concentrations (A) TNFα, (B) IL1β, (C) IL8, (D) IL6, (E) IL10, and (F) CXCL10 and sputum bacterial load of HI and MC in the subgroup of subjects qPCR positive for a single pathogen only. See Figure 1 and 2 legends for expansion of abbreviations. CHEST  , 46-55DOI: ( /chest ) Copyright © 2015 The American College of Chest Physicians Terms and Conditions


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