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Joint incongruity and biomarkers of bone metabolism as predictors of post-traumatic arthritis in mice  T.J. Vovos, B.D. Furman, J.L. Huebner, K.A. Kimmerling,

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Presentation on theme: "Joint incongruity and biomarkers of bone metabolism as predictors of post-traumatic arthritis in mice  T.J. Vovos, B.D. Furman, J.L. Huebner, K.A. Kimmerling,"— Presentation transcript:

1 Joint incongruity and biomarkers of bone metabolism as predictors of post-traumatic arthritis in mice  T.J. Vovos, B.D. Furman, J.L. Huebner, K.A. Kimmerling, G.M. Utturkar, L.E. DeFrate, V.B. Kraus, F. Guilak, S.A. Olson  Osteoarthritis and Cartilage  Volume 23, Pages A242-A243 (April 2015) DOI: /j.joca Copyright © Terms and Conditions

2 Figure 1(Top) Micro-CT images of representative fractures
Figure 1(Top) Micro-CT images of representative fractures. (Bottom) Metrics of joint incongruity after intra-articular fracture. Reference surface = prefecture; test surface = post-fracture. Osteoarthritis and Cartilage  , A242-A243DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Figure 2(Top) Representative color map of axial deviation with fracture healing. (Bottom) Significant strain- wise differences in fracture healing to 8 weeks post- fracture (data with different letters are significantly different). Osteoarthritis and Cartilage  , A242-A243DOI: ( /j.joca ) Copyright © Terms and Conditions

4 Figure 3. Correlations between total joint Mankin score for arthritis at 8 weeks post-fracture and post-fracture joint incongruity. Osteoarthritis and Cartilage  , A242-A243DOI: ( /j.joca ) Copyright © Terms and Conditions

5 Figure 4. Serum concentrations of bone biomarkers PINP and CTX-I with articular fracture in C57BL/6 (B6) and MRL/MpJ (MRL) mice. Osteoarthritis and Cartilage  , A242-A243DOI: ( /j.joca ) Copyright © Terms and Conditions


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