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ER Stress in Dendritic Cells Promotes Cancer

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Presentation on theme: "ER Stress in Dendritic Cells Promotes Cancer"— Presentation transcript:

1 ER Stress in Dendritic Cells Promotes Cancer
Christopher S. Garris, Mikael J. Pittet  Cell  Volume 161, Issue 7, Pages (June 2015) DOI: /j.cell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Model of XBP1-Driven ER Stress in Dendritic Cells
(Left) XBP1WT DC. (Right) XBP1KO DC. Tumor-derived factors activate lipid peroxidation within DCs in a ROS-dependent mechanism. Lipid peroxidation byproducts trigger ER stress responses that activate XBP1. XBP1 activation is connected to lipid synthesis pathways that ultimately increase lipid load within the DCs and inhibit DC-mediated T cell priming. Loss of XBP1 eliminates ER stress responses and lipid synthesis/accumulation and enhances DC ability to prime anti-tumor T cell responses. Cell  , DOI: ( /j.cell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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