1. Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor?
Melanie Philipp, Marc G. Caron 
Current Biology 
Volume 19, Issue 3, Pages R125-R127 (February 2009)
DOI: /j.cub
Copyright © 2009 Elsevier Ltd Terms and Conditions

2. Figure 1 Two arms of Smo signal transduction.
(A) Activation of Smo decreases the production of cAMP via inhibitory G proteins. PKA is inhibited and does not phosphorylate Gli. Thus, Gli is stabilized and able to initiate transcription. (B) Phosphorylation of active Smo by GRK2 prepares the association of Smo with β-arrestin 2. Subsequent interaction between β-arrestin 2 and Kif3A facilitates trafficking of Smo into primary cilia, possibly in vesicles. In the cilium, Smo signal transduction is initiated.
Current Biology  , R125-R127DOI: ( /j.cub )
Copyright © 2009 Elsevier Ltd Terms and Conditions