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Volume 46, Issue 5, Pages (June 2012)

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1 Volume 46, Issue 5, Pages 558-559 (June 2012)
Inhibiting the Inhibitor: The Role of RNF12 in TGF-β Superfamily Signaling  Caroline S. Hill  Molecular Cell  Volume 46, Issue 5, Pages (June 2012) DOI: /j.molcel Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 A Schematic Showing the Two Main Branches of TGF-β Superfamily Signaling Note that this is a simplification, as TGF-β can also lead to phosphorylation of Smad1/5 (reviewed in Wu and Hill, 2009). RNF12 is shown as a negative regulator of Smad7, which in turn negatively regulates the type I receptors in both signaling branches. P denotes phosphorylation. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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