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FOURIER Trial design: Patients with established cardiovascular disease on statin therapy were randomized to evolocumab 140 mg subcutaneous every 2 weeks.

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Presentation on theme: "FOURIER Trial design: Patients with established cardiovascular disease on statin therapy were randomized to evolocumab 140 mg subcutaneous every 2 weeks."— Presentation transcript:

1 FOURIER Trial design: Patients with established cardiovascular disease on statin therapy were randomized to evolocumab 140 mg subcutaneous every 2 weeks or 420 mg monthly (n = 13,784) versus placebo every 2 weeks (n = 13,780). Results (p < ) Cardiovascular death, MI, stroke, hospitalization for unstable angina, or coronary revascularization: 12.6% of the evolocumab group versus 14.6% of the placebo group (p < ) Any serious adverse event: 24.8% with evolocumab versus 24.7% with placebo 14.6 % 12.6 Conclusions Among patients with elevated cardiovascular risk on statin therapy, evolocumab versus placebo was effective at reducing adverse cardiovascular events Serious adverse events were similar between treatment groups Evolocumab Placebo Sabatine MS, et al. N Engl J Med 2017;Mar 17:[Epub]

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