1. Learning and memory: Basic Mechanisms
Chapter 18: Björn Brembs
Learning and memory: Basic Mechanisms
Thomas H. Brown, John H. Byrne, Kevin S. LaBar, Joseph E. LeDoux, Derick H. Lindquist, Richard E. Thompson and Timothy J. Teyler

2. Learning and Memory
Learning is the process by which memory is created

3. Classical conditioning
Where does the learning take place?
CS-US convergence point!
IMPORTANT!
CS: conditioned stimulus
US: unconditioned stimulus
CR: conditioned response
UR: unconditioned response

4. Classical conditioning
Aplysia californica (sea slug)

5. Classical conditioning
Aplysia californica (sea slug)
Sensori-motor circuitry:
Mechanism: Facilitation of sensori-motor synapses
Presynaptic post-
synaptic

6. Classical conditioning
Aplysia californica (sea slug)
Mechanism: Facilitation of sensori-motor synapses
Before:
After:
Pre-synapse
Post-synapse
Spike broadening:
Pre-synaptic

7. Classical conditioning
Aplysia californica (sea slug)
Mechanism: Facilitation of sensori-motor synapses
Pre-synapse
Post-synapse

8. Classical conditioning
Eyeblink conditioning
Auditory CS: tone
Visual CS: light

9. Classical conditioning
Eyeblink conditioning

10. Classical conditioning
Eyeblink conditioning CS CR US

11. Classical conditioning
Eyeblink conditioning

12. Classical conditioning
Eyeblink conditioning
Purkinje-Cells

13. Classical conditioning
Eyeblink conditioning CS US UR CS US

14. Classical conditioning
Eyeblink conditioning
Mechanism: Long-Term-Depression at parallel fiber – PC synapses

15. Classical conditioning
Eyeblink conditioning

16. Classical conditioning
Eyeblink conditioning CS US UR

17. Classical conditioning
Eyeblink conditioning

18. Classical conditioning
Eyeblink conditioning
Response: output
Stimulus: input

19. Operant conditioning
Skinner-Box

20. Operant conditioning
Aplysia californica feeding behavior

21. Operant conditioning Aplysia californica feeding behavior Pre-Test:
Training:

22. Operant conditioning Aplysia californica feeding behavior
Correlates in B51

23. Operant conditioning Aplysia californica feeding behavior
B51 single cell culture: in vitro operant conditioning