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Published byLauren Lawrence Modified over 5 years ago
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Heart failure and inflammation-related biomarkers as predictors of new-onset diabetes in the general population Navin Suthahar, Wouter C. Meijers, Frank P. Brouwers, Hiddo J.L. Heerspink, Ron T. Gansevoort, Pim van der Harst, Stephan J.L. Bakker, Rudolf A. de Boer International Journal of Cardiology Volume 250, Pages (January 2018) DOI: /j.ijcard Copyright © 2017 The Authors Terms and Conditions
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Fig. 1 (1a) Incidence of new-onset DM in 11 (±3) years starting from the second visit. (1b) Incidence of new-onset DM stratified by HF starting from the second visit (1c) Cumulative incidence of new-onset HF in 11 (±3) years starting from the first visit (1d) Cumulative incidence of new-onset HF stratified by DM starting from the first visit. HF, heart failure; DM, diabetes mellitus. International Journal of Cardiology , DOI: ( /j.ijcard ) Copyright © 2017 The Authors Terms and Conditions
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Fig. 2 Inflammation links insulin resistance in T2DM and HF.
Classic HF biomarkers have a predictive value in new-onset HF but are not associated with new-onset DM. On the other hand, inflammation-related biomarkers are significantly associated with the risk of development of both DM and HF, suggesting that complex immuno-inflammatory mechanisms might be responsible for insulin resistance and DM arising against the backdrop of HF. DM, diabetes mellitus; T2DM, type 2 diabetes mellitus; HF, heart failure. International Journal of Cardiology , DOI: ( /j.ijcard ) Copyright © 2017 The Authors Terms and Conditions
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