1. Advanced Biology
Burns
Skin Cancer

3. Burns: 1st Degree 2 million treated each year 12,000 die
Use rule of nines – see fig 5.8

5. Burns: 1st Degree Only Epidermis is damaged
Usually redness, swelling and pain
Heals in 1-2 weeks
SUNBURN

6. Burns: 1st Degree

7. Burns: 1st Degree
One severe sunburn can double your risk of skin cancer.

8. Sunburn

9. Burns: 2nd Degree Injure epidermis and upper region of dermis
Skin regeneration occurs w/in 3-4 weeks

10. Burns: 2nd Degree

11. Burns: 2nd Degree

12. Burns: 3rd Degree
Burns entire thickness of skin

13. Burns: 3rd Degree

14. Burns: 3rd Degree

15. Burns: 3rd Degree

16. Burns: 3rd Degree

17. Burns: 3rd Degree

18. Burns: 3rd Degree

19. Burns: 3rd Degree

21. Skin Grafting
Rejection by body

22. Skin Cancer
Benign = Non-cancerous
Malignant = Cancerous

23. Basal Cell Carcinoma Least malignant Most common skin cancer
Lesions on sun exposed face
Slow growing
W/ Surgery - 99 % full cure

26. Squamous Cell Carcinoma
Arises from keratinocytes of stratum spinosum
Scalp, ears
Grow rapidly
If detected early – complete cure is likely

28. Malignant Melanoma Cancer of melanocytes Most dangerous
Pigmented moles

30. ABCD Rule
A = Asymmetry
B = Border Irregularity
C = Color
D = Diameter

31. ABCD Rule A = sides do not match B = not smooth
C = several different colors
D = Larger than 6 mm

33. Developmental Aspects
Skin is formed
Fetus is covered with downy coat of delicate hairs called lanugo coat

34. Developmental Aspects
Vernix caseosa
Produced by sebaceous glands, protects fetus skin

35. Developmental Aspects
Rate of epidermal cell replacement slows
Skin thins
Susceptible to bruises

36. Developmental Aspects
Lubricating substances become deficient – skin dries out
Elastic fibers clump and degenerate

37. Developmental Aspects
Collagen fibers become fewer
Hypodermal layer decreases
Decrease in melanocytes and Langerhans’ cells
Hair loss