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Novel and uncommon antimicrobial resistance genes in livestock-associated methicillin- resistant Staphylococcus aureus  K. Kadlec, A.T. Feßler, T. Hauschild,

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Presentation on theme: "Novel and uncommon antimicrobial resistance genes in livestock-associated methicillin- resistant Staphylococcus aureus  K. Kadlec, A.T. Feßler, T. Hauschild,"— Presentation transcript:

1 Novel and uncommon antimicrobial resistance genes in livestock-associated methicillin- resistant Staphylococcus aureus  K. Kadlec, A.T. Feßler, T. Hauschild, S. Schwarz  Clinical Microbiology and Infection  Volume 18, Issue 8, Pages (August 2012) DOI: /j x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Comparison of the erm(A)– spc-carrying transposon Tn554 [32], the erm(A)-spc-vga(E)-carrying transposon Tn6133 [84], the dfrK-carrying transposon Tn559 [67], the fexA-carrying transposon Tn558 [31], the structurally closely related erm(B)-carrying transposons Tn917 and Tn551 [65,94], and the aacA-aphD-carrying transposon Tn4001 [65,94]. A distance scale in kb is given below each map. Insertion sequences are shown as boxes, with the arrow inside the box indicating the transposase gene. Genes coding for transposition functions are shown as grey arrows, and those coding for antimicrobial resistance properties as black arrows. White arrows indicate open reading frames (orfs) of unknown function. The arrowheads show the direction of transcription. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Comparative analysis of the tet(L)– dfrK region of plasmid pKKS2187 [64] and the tet(L)– dfrK–erm(T) region of plasmid pKKS25 [69] with the completely sequenced aadD–tet(L)– dfrK–vga(C)-carrying plasmid pKKS825 [82] and the vga(C)-carrying plasmid pCPS49 [81], all from porcine LA-MRSA CC398. The maps of the tet(L)-carrying plasmid pBC16 from Bacillus cereus [53] and the erm(T)-carrying plasmid pRW35 from Streptococcus pyogenes [73] have been included for comparative reasons. The areas of >95% nucleotide sequence identity between the different plasmids are indicated by grey shading. The arrows indicate the positions and extents of the different resistance genes; the arrowhead indicates the direction of transcription. A distance scale in kb is given below each map. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions


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