1. Correlation between Aβ deposition in the brain (PET) and the Aβ secondary structure distribution in plasma
Correlation between Aβ deposition in the brain (PET) and the Aβ secondary structure distribution in plasma The figure depicts transaxial and coronal sections of [18F]‐flutemetamol PET scans obtained from a cognitively healthy control (BioFINDER). The PET scan shows non‐specific binding of the radioligand in the white matter. The corresponding infrared amide I band for Aβ from this patient's EDTA‐blood plasma is presented below. The PET and infrared data correlate significantly with each other (rs = −0.397, P‐value = 5 × 10−4) (see Fig EV1).The figure depicts transaxial and coronal sections of [18F]‐flutemetamol PET scans obtained from a patient with prodromal AD (BioFINDER). The PET scan shows clearly increased cortical binding of [18F]‐flutemetamol. The corresponding infrared amide I band for Aβ from this patient's EDTA‐blood plasma is presented below. The PET and infrared data correlate significantly with each other (rs = −0.397, P‐value = 5 × 10−4) (see Fig EV1).
Andreas Nabers et al. EMBO Mol Med. 2018;emmm
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