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An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation  Teresa Song, BS, Ana B. Pavel, PhD, Huei-Chi Wen, MD, PhD,

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Presentation on theme: "An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation  Teresa Song, BS, Ana B. Pavel, PhD, Huei-Chi Wen, MD, PhD,"— Presentation transcript:

1 An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation 
Teresa Song, BS, Ana B. Pavel, PhD, Huei-Chi Wen, MD, PhD, Kunal Malik, MD, Yeriel Estrada, BS, Juana Gonzalez, PhD, Peter W. Hashim, MD, MHS, John K. Nia, MD, Danielle Baum, RN, Grace Kimmel, MD, Giselle K. Singer, BS, James G. Krueger, MD, PhD, Emma Guttman-Yassky, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 142, Issue 5, Pages e13 (November 2018) DOI: /j.jaci Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Box plots depicting serum chemokine/cytokine levels in patients with AA compared with those in healthy control subjects. Each marker was categorized under their respectively pathways of T-cell/NK-cell activation (A), TH1 (B-F), and TH2 (G-L). Black horizontal lines in boxes represent medians, whereas red horizontal lines in boxes represent means. Each black dot represents an individual patient. Significance above the lines compares patients with AA and healthy control subjects. +P < .1, *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology  , e13DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 A-E, Pearson correlation scatterplots of serum chemokines/cytokines with baseline SALT scores (Fig 2, A and B) and mRNA expression (Fig 2, C-E) in nonlesional and lesional scalp. F-T, mRNA expression correlates in nonlesional scalp to baseline SALT scores (Fig 2, F-N), whereas mRNA expression correlates in lesional scalp to baseline SALT score (Fig 2, O-T). Red points indicate each patient. R, Pearson correlation coefficient with associated P value. Linear regressions are presented as blue lines with their CIs (gray-shaded areas). Data are grouped according to major inflammatory/regulatory pathways. LS, Lesional; NL, nonlesional. Journal of Allergy and Clinical Immunology  , e13DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 A-S, Pearson correlation scatterplots of serum chemokines/cytokines with SALT scores (Fig E1, A-J) and mRNA expression (Fig E1, K-S) in nonlesional and lesional scalp. T-Y, Correlation of mRNA expression in nonlesional scalp to SALT scores. Red points indicate each individual patient. R, Pearson correlation coefficient with associated P value. Linear regressions are presented as blue lines with their CIs (gray-shaded areas). Data are grouped according to major inflammatory/regulatory pathways. LS, Lesional; NL, nonlesional. Journal of Allergy and Clinical Immunology  , e13DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Pearson correlation scatterplots of mRNA expression in nonlesional and lesional scalp with clinical severity/SALT score. Each marker was characterized under their respective pathway of keratins (A), T-cell/NK-cell activation (B), TH1 (C-E), TH2 (F-I), TH17 (J-L), and TH22 (M-N). Red points indicate each individual patient. R, Pearson correlation coefficient with associated P values. Linear regressions are presented as blue lines with their CIs (gray-shaded areas). Data are grouped according to major inflammatory/regulatory pathways. LS, Lesional; NL, nonlesional. Journal of Allergy and Clinical Immunology  , e13DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E3 Box plots depicting serum chemokines/cytokines in patients with AA without a history of atopy (n = 27) compared with healthy control subjects (n = 10). Serum markers profile exhibits similar increased as an entire cohort (n = 30), with better significance in CCL4 (E) and CCL11 (I). Each marker was categorized under their respective pathways of T-cell/NK-cell activation (A), TH1 (B-F), and TH2 (G-L). Black horizontal lines in boxes represent medians, whereas red horizontal lines in boxes represent means. Each black dot represents an individual patient. Significance above the lines compares patients with AA and healthy control subjects. +P < .1, *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology  , e13DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E4 Pearson heat map summarizes correlations between levels of serum chemokines/cytokines, mRNA levels of chemokines/cytokines in lesional (LS) and nonlesional (NL) AA scalp samples, clinical parameters, and SALT scores. Clusters shown by using dendrograms are shown on top of the heat map. +P < .1, *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology  , e13DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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