1. Effects of Hydrophobic Macromolecular Crowders on Amyloid β (16–22) Aggregation 
David C. Latshaw, Carol K. Hall 
Biophysical Journal 
Volume 109, Issue 1, Pages (July 2015)
DOI: /j.bpj
Copyright © 2015 Biophysical Society Terms and Conditions

2. Figure 1
Snapshots of the different types of aggregates observed as final configurations in our simulations. (A) The 5 Å hard-sphere crowder case results in fibrils with many β-sheets. (B) The 40 Å hard-sphere crowder case results in fibrils with few β-sheets. (C) The 5 Å crowders with 5ε interaction result in disordered oligomers. (D) The 40 Å crowders with 5ε interaction result in β-sheet oligomers. To see this figure in color, go online.
Biophysical Journal  , DOI: ( /j.bpj )
Copyright © 2015 Biophysical Society Terms and Conditions

3. Figure 2
(A–C) Number of peptides in disordered oligomers versus reduced time for crowder volume fraction ϕ = 0.10 with crowder diameters of (A) 40 Å, (B) 20 Å, and (C) 5 Å. To see this figure in color, go online.
Biophysical Journal  , DOI: ( /j.bpj )
Copyright © 2015 Biophysical Society Terms and Conditions

4. Figure 3
(A–C) Number of peptides in β-sheets versus reduced time for crowder volume fraction ϕ = 0.10 with crowder diameters of (A) 40 Å, (B) 20 Å, and (C) 5 Å. To see this figure in color, go online.
Biophysical Journal  , DOI: ( /j.bpj )
Copyright © 2015 Biophysical Society Terms and Conditions

5. Figure 4
(A and B) Geometric representation of (A) an 18-sided regular polygon with inscribed crowder circle and (B) three consecutive peptides in a β-sheet. In each case the red dots represent individual peptides and the red lines are backbone hydrogen bonds. To see this figure in color, go online.
Biophysical Journal  , DOI: ( /j.bpj )
Copyright © 2015 Biophysical Society Terms and Conditions

6. Figure 5
(A–C) Number of peptides in fibrils versus reduced time for crowder volume fraction ϕ = 0.10 with crowder diameters of (A) 40 Å, (B) 20 Å, and (C) 5 Å. To see this figure in color, go online.
Biophysical Journal  , DOI: ( /j.bpj )
Copyright © 2015 Biophysical Society Terms and Conditions

7. Figure 6
Global phase diagram summarizing the types of aggregates present in each simulation at crowder volume fraction ϕ = 0.10 for different values of the crowder diameter, D, and interaction strength, Xε. F, fibrils; B, ordered β-sheet oligomers; D, disordered oligomers. To see this figure in color, go online.
Biophysical Journal  , DOI: ( /j.bpj )
Copyright © 2015 Biophysical Society Terms and Conditions