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Volume 18, Issue 3, Pages (June 2011)

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1 Volume 18, Issue 3, Pages 235-242 (June 2011)
Montelukast, a leukotriene receptor antagonist abrogates lipopolysaccharide-induced toxicity and oxidative stress in rat liver  Ahmed M. Mohamadin, Ahmed A. Elberry, Mohamed A. Elkablawy, Hala S. Abdel Gawad, Fahad A. Al-Abbasi  Pathophysiology  Volume 18, Issue 3, Pages (June 2011) DOI: /j.pathophys Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Effect of montelukast (MNT) on production of inflammatory cytokines TNF-α (A) and IL-1β (B) in the serum of LPS-induced hepatotoxicity in male rats. Data are expressed as means±SEM (n=10). *Significantly different from control group (P<0.01). #Significantly different from LPS-treated group (P<0.01). Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Effects of montelukast (MNT) on changes in malondialdehyde (A) and protein carbonyl content (PCC) levels in LPS-induced hepatotoxicity in rats. Data are expressed as means±SEM (n=10). *Significantly different from control group (P<0.01). #Significantly different from LPS-treated group (P<0.01). Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Effects of montelukast (MNT) on changes in levels of tissue reduced glutathione (A), oxidized glutathione (B) and GSH/GSSG ratio (C) in LPS-induced hepatotoxicity in rats. Data are expressed as means±SEM (n=10). *Significantly different from control group (P<0.01). #Significantly different from LPS-treated group (P<0.01). Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 4 Effects of montelukast (MNT) on changes in activity of myeloperoxidase (MPO) in LPS-induced hepatotoxicity in rats. Data are expressed as means±SEM (n=10). *Significantly different from control group (P<0.01). #Significantly different from LPS-treated group (P<0.01). Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 5 (A) Control rat liver: liver showing normal architecture. (B) Normal histology was observed after MNT per se treatment. (C) LPS treated rat liver: inflammatory cell infiltration and focal necrosis. (D) MNT+LPS treated rat liver: normal hepatocytes with mild portal inflammation (H&E, 20×). Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions


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