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The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype  Marie-Hélène Dizier, PhD, Patricia Margaritte-Jeannin, PhD,

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Presentation on theme: "The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype  Marie-Hélène Dizier, PhD, Patricia Margaritte-Jeannin, PhD,"— Presentation transcript:

1 The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype 
Marie-Hélène Dizier, PhD, Patricia Margaritte-Jeannin, PhD, Anne-Marie Madore, PhD, Miriam Moffatt, PhD, Myriam Brossard, MSc, Nolwenn Lavielle, MSc, Chloé Sarnowski, MSc, Jocelyne Just, MD, William Cookson, MD, Mark Lathrop, PhD, Catherine Laprise, PhD, Emmanuelle Bouzigon, MD, PhD, Florence Demenais, MD  Journal of Allergy and Clinical Immunology  Volume 134, Issue 3, Pages e1 (September 2014) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Plot of FBAT results (expressed as −log10[P]) in EGEA families using 2042 genotyped SNPs in the 1p31 linkage region (53-63 Mb from pter). The linkage peak is located at 58 Mb. The identity of the most significant SNP (rs ) is indicated. B, Visualization of results in the interval of associated SNPs (spanning 10 kb on each side of rs ) with LocusZoom software. The y-axis shows the results −log10(P) of logistic regression analysis in the EGEA discovery sample (circles) and of the meta-analysis of the EGEA, SLSJ, and MRC samples (triangle). The position of the SNPs in megabases (build 36.3) is shown on the x-axis. The SNP rs is colored purple, and the degree of LD between that SNP and the other SNPs is indicated by color according to the key, with red being the highest degree of LD. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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