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Frequent Human Herpesvirus-6 Viremia But Low Incidence of Encephalitis in Double- Unit Cord Blood Recipients Transplanted Without Antithymocyte Globulin 

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Presentation on theme: "Frequent Human Herpesvirus-6 Viremia But Low Incidence of Encephalitis in Double- Unit Cord Blood Recipients Transplanted Without Antithymocyte Globulin "— Presentation transcript:

1 Frequent Human Herpesvirus-6 Viremia But Low Incidence of Encephalitis in Double- Unit Cord Blood Recipients Transplanted Without Antithymocyte Globulin  Amanda L. Olson, Parastoo B. Dahi, Junting Zheng, Sean M. Devlin, Marissa Lubin, Anne Marie Gonzales, Sergio A. Giralt, Miguel- Angel Perales, Esperanza B. Papadopoulos, Doris M. Ponce, James W. Young, Nancy A. Kernan, Andromachi Scaradavou, Richard J. O’Reilly, Trudy N. Small, Genovefa Papanicolaou, Juliet N. Barker  Biology of Blood and Marrow Transplantation  Volume 20, Issue 6, Pages (June 2014) DOI: /j.bbmt Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 The incidence and severity of HHV-6 viremia in the first 100 days after CBT (N = 125) Nearly all patients reactivated, 77% ≥ 1000, but only 6% > 100,000 and none ≥ 1,000,000. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Relationship between HHV-6 viral load and absolute lymphocyte (ALC) recovery after CBT. There was a significant association between absolute lymphocyte recovery (measured in K/μL) and resolution of HHV-6 viremia. The HHV-6 viral load in the first 60 days post-CBT is shown in black circles and ALC recovery is shown in red stars (all values for all patients). The solid lines are splines over time for HHV-6 viremia (black) and ALC recovery (red), respectively. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions


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