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Association between Single-Nucleotide Polymorphisms in Selectin Genes and Immunoglobulin A Nephropathy Takashi Takei, Aritoshi Iida, Kosaku Nitta, Toshihiro Tanaka, Yozo Ohnishi, Ryo Yamada, Shiro Maeda, Tatsuhiko Tsunoda, Sachiyo Takeoka, Kyoko Ito, Kazuho Honda, Keiko Uchida, Ken Tsuchiya, Yasushi Suzuki, Tomoaki Fujioka, Takashi Ujiie, Yutaka Nagane, Satoru Miyano, Ichiei Narita, Fumitake Gejyo, Hiroshi Nihei, Yusuke Nakamura The American Journal of Human Genetics Volume 70, Issue 3, Pages (March 2002) DOI: /339077 Copyright © 2002 The American Society of Human Genetics Terms and Conditions
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Figure 1 High-density map and association with IgAN of SNPs in the selectin gene cluster at chromosome 1q SNPs (downward arrows) are numbered for E-selectin (SELE1–13), L-selectin (SELL1–15), and P-selectin (SELP1–6), in the telomeric to centromeric direction. The American Journal of Human Genetics , DOI: ( /339077) Copyright © 2002 The American Society of Human Genetics Terms and Conditions
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Figure 2 Immunohistochemical localization of E-selectin and L-selectin in the renal tissues of patients with IgAN. Control tissues were normal portions obtained from patients who underwent nephrectomy because of renal tumor. The monoclonal antibodies used in this study were anti-human E-selectin (clone 1.2B6) and anti-human L-selectin (clone FMC46) (DAKO Japan). A, Control E-selectin. B, IgAN E-selectin. C, Control L-selectin. D, IgAN L-selectin. Original magnification ×200. The American Journal of Human Genetics , DOI: ( /339077) Copyright © 2002 The American Society of Human Genetics Terms and Conditions
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