1. Coherent X-ray Imaging WBS 1.3
Sébastien Boutet - CXI Instrument Scientist
Paul Montanez - CXI Lead Engineer
July 15, 2009

2. CXI Goals and Physics Requirements CXI Instrument Overview
Outline
CXI Science
CXI Goals and Physics Requirements
CXI Instrument Overview
WBS 1.3 Scope
Early Science Instrument Scope
Major Component Status
Engineering/Design Status
Critical Path
Cost & Schedule Performance
Progress since April Status Review
Milestones
Summary

3. Coherent Diffractive Imaging of Biomolecules

4. CXI Instrument Science
Protein molecule injection
To mass spectrometer
X-ray diffraction pattern
LCLS
detector
3D biological imaging beyond the damage limit
Single reproducible biomolecules that can’t be crystallized
Proteins
Membrane Proteins
Viruses
Molecular complexes
Molecular machines
Biomolecular structure determination from nanocrystals
No need for large high quality crystals
2D imaging of irreproducible samples
Live hydrated cells with particle injector
Nanoparticles
Quantum dots
Amorphous nanoparticles
High fluence X-ray-matter interactions

5. CXI Instrument Goals/Requirements
Perform imaging of single particles at highest spatial resolution achievable using single LCLS pulses
Image biological nanoparticles beyond the classical damage limit using single LCLS pulses
Global Requirements (SP )
Tailor and characterize X-ray beam parameters
Spatial Profile
Intensity
Repetition rate
Deliver the sample to the beam and control its environment
Key Performance Parameters
4-20 keV energy range
Using the fundamental and third harmonic
Energy Bandwidth
Set by LCLS beam
Particle Injector
nm size range

6. CXI Instrument Location
Near Experimental Hall
AMO
SXR
X-ray Transport Tunnel
XPP
CXI
Endstation
XCS
Source to Sample distance : ~ 440 m
MEC
Far Experimental Hall

7. Far Experimental Hall CXI Control Room Coherent X-ray Imaging
Lab Area
XCS Control Room
Matter in Extreme Conditions
Instrument
X-ray Correlation Spectroscopy
Instrument
Coherent X-ray Imaging
Instrument

8. CXI Instrument Overview
Guard Slits
Requirement
Device
Remove X-ray beam halo
X-ray Guard Slits
Tailor X-ray intensity
Attenuators
Tailor X-ray repetition rate
Pulse Picker
Characterize X-ray pulse intensity
Intensity Monitor
Characterize X-ray spatial profile
Profile Monitor
Characterize X-ray focus
Wavefront Monitor
Tailor focal spot size to the sample
X-ray Focusing Lenses
Align experiment without X-ray beam
Reference Laser
Maximize X-ray flux on sample
1 micron Kirkpatrick-Baez Mirrors
0.1 micron Kirkpatrick-Baez Mirrors
Minimize air scatter and background
Position sample and final apertures
Sample environment
Position sample environment
Instrument Stand
Deliver particles to the X-ray beam in
Particle Injector
Measure X-ray scattering pattern
2D X-ray Detector (Utilizing the LCLS Detector)
Position X-ray area detector
Detector Stage
Analysis of sample fragments after Coulomb explosion
Ion Time-of-Flight
Diagnostics
XRT
Photon Shutter
Attenuators
Pulse Picker
Focusing Lenses
Reference Laser
Guard Slits
Diagnostics
Guard Slits
1 µm KB Mirrors
Diagnostics
Guard Slits
0.1 µm KB Mirrors
0.1 µm Sample Environment
Particle Injector
Ion TOF-MS
FEH Hutch 5
Detector Stage
Guard Slits
Diagnostics
1 µm Sample Environment
Particle Injector
Ion TOF-MS
Detector Stage
Wavefront Monitor
Beam Dump

9. WBS 1.3 – Early Science/CD-4 Deliverables
Early Science: Installation Early Finish – June 2011
CD-4: Installation Early Finish – August 2011

10. CXI Instrument CXI Early Science CXI Engineering/Design staff
Diagnostics/Common Optics
Reference Laser
Diagnostics &
Wavefront Monitor
1 micron Sample Environment
1 micron KB
CXI Engineering/Design staff
Armin Busse, Kay Fox, Paul Montanez, William Olson, Michael Ramos, Donald Schafer, Nathaniel Stewart

11. CXI Instrument CXI CD-4 CXI Engineering/Design staff
Diagnostics/Common Optics
Reference Laser
Diagnostics &
Wavefront Monitor
1 micron Sample Environment
0.1 micron KB & Sample Environment,
Particle Injector and IToF
1 micron KB
CXI Engineering/Design staff
Armin Busse, Kay Fox, Paul Montanez, William Olson, Michael Ramos, Donald Schafer, Nathaniel Stewart

12. Diagnostics and Common Optics
Guard Slits
Diagnostics
XRT
Photon Shutter
Attenuators
Pulse Picker
Focusing Lenses
Reference Laser
Guard Slits
Diagnostics
Guard Slits
1 µm KB Mirrors
Diagnostics
Guard Slits
Requirement
Device
Remove X-ray beam halo
X-ray Guard Slits
Tailor X-ray intensity
Attenuators
Tailor X-ray repetition rate
Pulse Picker
Characterize X-ray pulse intensity
Intensity Monitor
Characterize X-ray spatial profile
Profile Monitor
Characterize X-ray focus
Wavefront Monitor
Tailor focal spot size to the sample
X-ray Focusing Lenses
0.1 µm KB Mirrors
0.1 µm Sample Environment
Particle Injector
Ion TOF-MS
FEH Hutch 5
Detector Stage
Guard Slits
Diagnostics
1 µm Sample Environment
Particle Injector
Ion TOF-MS
Detector Stage
Wavefront Monitor
Beam Dump
DCO Details will be Discussed in the breakout

13. CXI Reference Laser (WBS 1.3.03.1)
XRT
Vacuum chamber cover/laser cover removed/sectioned for clarity
Purpose
Rough alignment of the experiment without the X-ray beam
Engineering/Design Status
PRD & ESD released
PDR completed March 2009
FDR scheduled for July
Use mechanical designs for the vacuum chamber and 6-DOF alignment stage that have previously sustained reviews
Leveraging existing designs (when applicable) reduces our overall engineering/design effort. Additionally, helps to ensure commonality within the LUSI instruments
Budget at Completion (BAC) ≈ $126K
FEH Hutch 5

14. CXI 1µm KB system (WBS 1.3.02.02) Purpose Engineering/Design Status
XRT
Purpose
Produce a 1 µm focus
Focal lengths
8.2 m for M1
7.8 m for M2
Engineering/Design Status
PRD, ESD & SOWs released
Prime vendor to provide complete and integrated KB system, including:
Figured & Polished Substrates (subcontractor)
Mirror Mechanics/Manipulators
Vacuum chamber and support stand
MOU for independent metrology/coating of the substrates
Negotiating with LLNL based on prior experience with LCLS OMS mirrors
Procurement Activities
Recommended a vendor to the Source Selection Official on April 27th
Awarded to Bruker Advanced Supercon with JTEC mirrors on July
Delivery November 2010
Budget at Completion (BAC) ≈ $1,280K ($925,000 in long lead procurement)
FEH Hutch 5

15. Particle Injector (WBS 1.3.04.01)
Purpose
Deliver support-free single particles to the LCLS beam
Engineering/Design Status
PRD & ESD released
Existing Injector design from LLNL
CXI is advancing the current design
Optimization of particle beam throughput
Remote operation of equipment
SLAC/LLNL Memorandum of Understanding (MOU) signed-off February 2009
$500K over 4 fiscal years
BAC ≈ $1,470K
XRT
FEH Hutch 5

16. CXI 1µm Sample Environment (WBS 1.3.05.01.01)
Purpose
Position samples on grids and apertures
Maintain high vacuum
Compatible with 1 µm focus and unfocused beam
Engineering/Design Status
PRD & ESD released
PDR completed March 2009
FDR “Early Finish” scheduled for November 2009
Plan to accelerate FDR to August 2009
Planning requisition created for the in-vacuum stages
BAC ≈ $620K
XRT
FEH Hutch 5

17. CXI 1 µm Precision Instrument Stand (WBS 1.3.05.01.02)
XRT
Purpose
Support /Interface with 1µm Sample Chamber and Detector Stage (in all experimental configurations)
Engineering/Design Status
PRD & ESD released
PDR completed May 15, 2009
FDR “Early Finish” scheduled for September 2009
Plan to accelerate FDR to August 2009
BAC ≈ $240K
FEH Hutch 5

18. Detector Stage (WBS 1.3.05.01.03) Purpose
Center the detector hole on the direct beam
Position the detector at the appropriate distance
from the interaction region
Detector not in CXI LUSI scope
Part of LCLS Project scope
CXI team has weekly interface meeting with LCLS detector group
Engineering/Design Status
PRD, ESD, SOWs & ICDs released
Purchase order placed in March 2009 with a local design firm for the mechanical design and drafting of the CXI Detector Stage – CXI was resource limited
Move design forward in the schedule
Vendor design reviews
PDR completed May 15, 2009FDR “Early Finish” scheduled for January 2010
Plan to accelerate FDR to August 2009
BAC ≈ $330K
XRT
FEH Hutch 5
Cornell/SLAC detector with variable aperture

19. CXI 1 micron Sample Environment
Particle injector
Detector Stage
(upstream position)
LCLS Beam
Sample Chamber
Precision Instrument Stand
Detector Stage
(back position)

20. CXI 0.1µm Sample Environment (WBS 1.3.05.01.01)
CXI 0.1 µm KB Mirrors/Sample Environment & Stand (WBS , and )
XRT
CXI 0.1µm KB system (WBS )
Purpose
Produce a 0.1 µm focus
Focal lengths
0.9 m for M1
0.5 m for M2
Identical to 1 micron KB System in every way except for the mirror curvature
CXI 0.1µm Sample Environment (WBS )
Provide the sample environment
Extend vacuum enclosure by ~600 mm for sample area
CXI 0.1µm Precision Instrument Stand (WBS )
Support the KB System and the Sample Chamber
Engineering/Design Status
0.1µm System
PRD, ESD & SOWs released
Procurement included as an “option” for the CXI 1µm KB contract
Option to be exercised upon CD-3 approval
BAC ≈ $1,180K
FEH Hutch 5

21. CXI Critical Path
KB Mirror AWARD & Vendor Design
KB Mirror Design/Fabrication Effort
Post Vendor Effort and Installation
Critical path (thru 1µm KB System) has -17days of schedule contingency
KB Mirror Installation Effort

22. Progress Since April Status Review
Design Reviews
Preliminary Design Reviews completed
CXI Detector Stage & 1µm Precision Instrument Stand – May 2009
CXI Final Instrument Design Review
June
Advanced the design of 4 key CXI components to support a FDR in August 2009
Purchase Requisition for In-vacuum stages for Sample Chamber
Planning req to be awarded after CD-3
All documentation completed & released
PRDs, ESDs, SOWs, ICDs, etc.
1µm Kirkpatrick-Baez mirror system
Vendor selected by Technical Committee April
Awarded July
Ready to act on option for 0.1 µm KB after CD-3
Option set to expire on August 31st
Key project Milestones
Preliminary Instrument Design Review Dec 2007
CD July 2008
Advanced Procurement Review October 2008
Final Instrument Design Review June 2009
Ready for Early Science June 2011
Ready for CD August 2011

23. Cost & Schedule Performance

24. Summary The CXI instrument is versatile:
X-ray optics can tailor FEL parameters for users
Sample environment can accommodate multiple experimental configurations
CXI designs are mature and concepts are based on proven developments made at FLASH and SR sources
The design risks are low
Risks are identified and monitored in the risk registry
Most major risks associated with the KB mirror systems have been retired
Remaining KB risks will be addressed during design/manufacture and testing
Final Instrument Design Review completed on June
Replanning of LUSI WBS 1.3 (CXI) due to ARRA funding is completed
CXI schedule is being accelerated
Advancement of the complete instrument and readiness for CD-4
User operation start planned for 2011
Design is mature and CXI is ready for CD-3