1. • First practical method for asymmetric hydrocyantion of a 1,3-diene
Asymmetric Hydrocyanation of 1,3-Dienes T. V. RajanBabu, Department of Chemistry, The Ohio State University
(Org. Lett. 2006, 8, 4657)
• Asymmetric synthesis using feed stock carbon sources could have major impact
on how fine chemicals are synthesized and manufactured
• First practical method for asymmetric hydrocyantion of a 1,3-diene
• A new, highly selective protocol for Ni-catalyzed hydrocyanation of dienes reported
• Low temperatures, high yields (71-95%)
• High regioselectivity approaching 99% for several different dienes.
• High enantioselectivity
• Reactivity differences between these dienes illustrated
• Generation of quaternary centers
• Cyano derivatives are useful for the synthesis of amines, aldehydes and acids