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Pancreaticobiliary Cancers With Deficient Methylenetetrahydrofolate Reductase Genotypes
Hiroyuki Matsubayashi, Halcyon G. Skinner, Christine Iacobuzio-donahue, Tadayoshi Abe, Norihiro Sato, Taylor Sohn Riall, Charles J. Yeo, Scott E. Kern, Michael Goggins Clinical Gastroenterology and Hepatology Volume 3, Issue 8, Pages (August 2005) DOI: /S (05) Copyright © 2005 American Gastroenterological Association Terms and Conditions
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Figure 1 Correlation between MTHFR 677 genotype and % of LINE1 methylation. The average of LINE1 methylation level was decreased from 677CC/C genotype (32.5% ± 10.3%), via 677CT (26.0% ± 8.9%) to 677TT/T (24.4% ± 8.5%). White circle, pancreatic cancer cell line; gray circle, breast cancer cell line; black, colon cancer cell line. *P = .014 by Kruskal-Wallis test. Clinical Gastroenterology and Hepatology 2005 3, DOI: ( /S (05) ) Copyright © 2005 American Gastroenterological Association Terms and Conditions
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