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Immunomodulation Effects of Mesenchymal Stromal Cells on Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation  Ke Zhao, Rui Lou,

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Presentation on theme: "Immunomodulation Effects of Mesenchymal Stromal Cells on Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation  Ke Zhao, Rui Lou,"— Presentation transcript:

1 Immunomodulation Effects of Mesenchymal Stromal Cells on Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation  Ke Zhao, Rui Lou, Fen Huang, Yanwen Peng, Zujun Jiang, Ke Huang, Xiuli Wu, Yu Zhang, Zhiping Fan, Hongsheng Zhou, Can Liu, Yang Xiao, Jing Sun, Yangqiu Li, Peng Xiang, Qifa Liu  Biology of Blood and Marrow Transplantation  Volume 21, Issue 1, Pages (January 2015) DOI: /j.bbmt Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Characteristics of human MSCs. (A) The morphology of human MSCs (passage 4) monitored by phase contrast microscopy. (B) Oil red O staining of adipogenic differentiated human MSCs. (C) Alizarin red S staining of osteogenic differentiated human MSCs. (D) Flow cytometric analysis of surface markers of human MSCs. Scale bar = 200 μm. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Cumulative incidence of CMV viremia (A), CMV-associated diseases (B), EBV viremia (C), and EBV-associated diseases (D). The 1-year cumulative incidence of CMV viremia and CMV-associated diseases was 53.1% ± 6.5% and 18.5% ± 5.8% in the MSC group compared with 46.9% ± 7.3% and 6.2% ± 5.1% in the control group (P = .488 and P = .215). The 1-year cumulative incidence of EBV viremia and EBV-associated diseases was 30.8% ± 10.1% and 24.3% ± 6.7% in the MSC group compared with 37.4% ± 8.2% and 12.8% ± 4.3% in the control group (P = .597 and P = .478). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Lymphocyte subsets of CD3+CD4+ T cells (A), CD3+CD8+ T cells (B), and CD4+CD25+Foxp3+ Tregs (C) before and 4, 8, 12, 24, and 36 weeks after the study treatments. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions


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