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Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population  S. Maeda, N. Osawa, T. Hayashi, S. Tsukada, M.

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Presentation on theme: "Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population  S. Maeda, N. Osawa, T. Hayashi, S. Tsukada, M."— Presentation transcript:

1 Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population  S. Maeda, N. Osawa, T. Hayashi, S. Tsukada, M. Kobayashi, R. Kikkawa  Kidney International  Volume 72, Pages S43-S48 (August 2007) DOI: /sj.ki Copyright © 2007 International Society of Nephrology Terms and Conditions

2 Figure 1 Combinational effects by which RAS gene polymorphisms confer susceptibility to diabetic nephropathy.17 The upper table indicates the results of a step-wise logistic regression analysis. The lower panel indicates the increased odds ratio according to the number of risk genotypes. 95% CIs are indicated in parenthesis. Kidney International  , S43-S48DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions

3 Figure 2 The results of genome-wide screening for diabetic nephropathy using 94 nephropathy cases and 94 control subjects.19 Kidney International  , S43-S48DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions

4 Figure 3 LD mapping around the marker SNPs in the genome-wide screening. Data from the HapMap database for the Japanese are presented. (a) SLC12A3 locus at chromosome 16q13. *Marker SNP (rs ). (b) ELMO1 locus at chromosome 7p14. *Marker SNP (rs741301). Kidney International  , S43-S48DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions

5 Figure 4 The results of genome-wide screening for type II diabetes.23 (a) Results of the first and second tests. (b) Detailed result of the second test. *TFAP2B locus. Kidney International  , S43-S48DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions

6 Figure 5 The TFAP2B locus at chromosome 6p12. Upper panel: LD mapping for this locus obtained from the HapMap database. Lower panel: structure of the TFAP2B gene. *Marker SNP (rs ). S-allele, disease susceptibility allele and N-allele, major allele. Kidney International  , S43-S48DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions


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