1. HSC DC - precursors DC Lymphoid precursor Lymphoid Myeloid precursor
IL-7Ra -
Pax-5 -
SCL +
c-kit +
Lymphoid precursor
IL-7Ra +
Pax-5 +
SCL -
Myeloid precursor
DC - precursors
c-kit - DC
Mouse DC differentiation model
DC may be generated by two separate differentiation routes from either lymphoid- or myeloid-committed precursors, or alternatively by a common DC differentiation pathway through DC-precursors, independently from lymphoid and myeloid progenitors. The biological significance of this model, including the analysis of the differential expression of IL-7Ra, Pax-5, SCL and c-kit by DC-precursors, is discussed in the printed version of the paper. DC: dendritic cell, HSC: hematopoietic stem cell.
Carlos Ardavín
A06736