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Spectraplakins: The Cytoskeleton's Swiss Army Knife

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Presentation on theme: "Spectraplakins: The Cytoskeleton's Swiss Army Knife"— Presentation transcript:

1 Spectraplakins: The Cytoskeleton's Swiss Army Knife
Nicholas H. Brown  Cell  Volume 135, Issue 1, Pages (October 2008) DOI: /j.cell Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 ACF7 Coordinates Actin and Microtubules in Cytoskeleton-Focal Adhesion Dynamics The spectraplakin ACF7 directly binds both microtubules and actin filaments and has an actin-dependent ATPase activity. In wild-type cells (left), ACF7 coordinates the targeting of microtubules to focal adhesions, where they direct disassembly of the adhesion contact and promote cell movement. ACF7-deficient cells (right) show altered microtubule organization accompanied by a loss of microtubule targeting to focal adhesions, which become stabilized and enlarged. Cell  , 16-18DOI: ( /j.cell ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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