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The Hedgehog Hold on Homeostasis

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Presentation on theme: "The Hedgehog Hold on Homeostasis"— Presentation transcript:

1 The Hedgehog Hold on Homeostasis
Ciara Metcalfe, Christian W. Siebel  Cell Stem Cell  Volume 17, Issue 5, Pages (November 2015) DOI: /j.stem Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Hedgehog Signaling Sets Up an Epithelial-Mesenchymal Feedback Loop to Maintain Quiescence in the Adult Lung Shh, expressed primarily in the secretory cells of the airway epithelium, drives Hh pathway activity in the adjacent mesenchyme and maintains its quiescence. Epithelial injury attenuates the signal, which relieves the quiescent hold on the fibroblasts, enabling them to proliferate. Mesenchymal expansion is in turn associated with increased proliferation of the epithelial layer, reestablishing the source of Hh ligand and a return to quiescence. Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2015 Elsevier Inc. Terms and Conditions


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