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Lack of fludeoxyglucose F 18 uptake in posttreatment positron emission tomography as a significant predictor of survival after subsequent surgery in multimodality.

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Presentation on theme: "Lack of fludeoxyglucose F 18 uptake in posttreatment positron emission tomography as a significant predictor of survival after subsequent surgery in multimodality."— Presentation transcript:

1 Lack of fludeoxyglucose F 18 uptake in posttreatment positron emission tomography as a significant predictor of survival after subsequent surgery in multimodality treatment for patients with locally advanced esophageal squamous cell carcinoma  Ichirou Higuchi, MD, Takushi Yasuda, MD, Masahiko Yano, MD, Yuichirou Doki, MD, Hiroshi Miyata, MD, Mitsuaki Tatsumi, MD, Hironori Fukunaga, MD, Shuji Takiguchi, MD, Yoshiyuki Fujiwara, MD, Jun Hatazawa, MD, Morito Monden, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 136, Issue 1, Pages e3 (July 2008) DOI: /j.jtcvs Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Correlation between tumor size (maximum cross-sectional area of resected tumor) and posttreatment maximum standardized uptake value (SUVmax) in primary tumor. Posttreatment maximum standardized uptake value and tumor size ranged from 1.03 to and from 0 mm2 to mm2, respectively n = 50, y = × x , r = 0.898, R2 = 0.806, P < .0001). The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Correlation between posttreatment positron emission tomographic (PET) diagnosis at primary tumor site and postoperative survival by Kaplan–Meier analysis in neoadjuvant group. A, Cause-specific survival from data of all 50 patients. B, Disease-free survival from data of 48 patients, excluding 2 cases of noncurative resection (R2). The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

4 Relationship between histologic response grade in primary tumor after chemoradiotherapy and residual tumor size. Size of 33 mm2, indicated by arrow, represents cutoff value used to distinguish between grade 1 or worse histologic nonresponse and grade 2 or better histologic response. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

5 Example of positron emission tomographic imaging before (A) after (B) chemotherapy, with histologic finding of residual tumor (C). Maximum standardized uptake value of primary tumor decreased from to 1.63 after therapy. Size of residual tumor was 1.3 mm2, and histologic response was assessed as grade 2. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions


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