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Volume 136, Issue 1, Pages (January 2009)

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Presentation on theme: "Volume 136, Issue 1, Pages (January 2009)"— Presentation transcript:

1 Volume 136, Issue 1, Pages 131-137 (January 2009)
Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome  Juul T. Wijnen, Richard M. Brohet, Ronald van Eijk, Shanty Jagmohan–Changur, Anneke Middeldorp, Carli M. Tops, Mario van Puijenbroek, Margreet G.E.M. Ausems, Encarna Gómez García, Frederik J. Hes, Nicoline Hoogerbrugge, Fred H. Menko, Theo A.M. van Os, Rolf H. Sijmons, Senno Verhoef, Anja Wagner, Fokko M. Nagengast, Jan H. Kleibeuker, Peter Devilee, Hans Morreau, David Goldgar, Ian P. Tomlinson, Richard S. Houlston, Tom van Wezel, Hans F.A. Vasen  Gastroenterology  Volume 136, Issue 1, Pages (January 2009) DOI: /j.gastro Copyright © 2009 AGA Institute Terms and Conditions

2 Figure 1 (A) Unadjusted overall cumulative CRC risk for MMR-gene carriers and allele rs (B) Unadjusted cumulative CRC risk for male MMR-gene carriers and allele rs Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

3 Figure 2 (A) Unadjusted overall cumulative CRC risk for MMR-gene carriers and allele rs (B) Unadjusted cumulative CRC risk for male MMR-gene carriers and allele rs (C) Unadjusted cumulative CRC risk for female MMR-gene carriers and allele rs Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

4 Figure 3 (A) CRC risk in male carriers according to number of risk alleles of rs and rs adjusted for birth cohort and type of MMR gene. (B) CRC risk in female carriers according to number of risk alleles of rs and rs adjusted for birth cohort and type of MMR gene. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions


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