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Sumoylation Stabilizes Smoothened to Promote Hedgehog Signaling

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Presentation on theme: "Sumoylation Stabilizes Smoothened to Promote Hedgehog Signaling"— Presentation transcript:

1 Sumoylation Stabilizes Smoothened to Promote Hedgehog Signaling
Yun Qi, Han Liu, Xinhua Lin  Developmental Cell  Volume 39, Issue 4, Pages (November 2016) DOI: /j.devcel Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Post-translational Modifications of Smo and Their Effect on Hh Signal Transduction Ubiquitinated Smo is subject to constant turnover by the proteasome and the lysosome. Upon Hh activation, phosphorylation and sumoylation work in parallel to antagonizes Smo’s ubiquitin-mediated proteolysis. Smo thus accumulates on the cell surface and further transduces the Hh signal to activate target gene expression. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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